Should the best mismatched donor be chosen based on KIR typing? KIR role in transplantation and implications

Written by Vera Siffnerová (FAS, Omixon) A choice of the most suitable donor for each transplant patient has always been the main focus and challenge for the whole team that is involved in the selection process. There is a high number of criteria that are evaluated, different approaches and...

 

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Mortality Prediction Hidden in our Genome

The success of hematopoietic stem cell transplant (HSCT) is influenced by many factors including HLA mismatches, variations in the major histocompatibility complex (MHC) region, minor histocompatibility targets of allorecognition, regulatory elements that affect gene expression and genetic variation that affects immune responses (Table 1, Table 2). The individual contribution...

 

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It Is Not You Who Chooses Your Partner… But Your HLA Genes!

Written by Nina Lauterbach, PhD (Field Application Scientist, Omixon) Animals, and us humans, are daily under attack by viruses and other pathogens. Fortunately, we are equipped with the Major Histocompatibility Complex (MHC) as an efficient and adaptable fighting mechanism to deal with these threatening events. This complex is encoded...

 

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