High Accuracy and High Precision HLA Typing Using Illumina Reads: Typing Algorithm and Perspectives on Novel Allele Discovery

24/02/2015

Authors: György Horváth, Krisztina Rigó, Tim Hague, Attila Bérces, Szilveszter Juhos Abstract: Wide acceptance of high-throughput next-generation sequencers in medicinal genomics and clinics brought the promise of fast HLA typing. We are presenting the algorithmic challenges and workflow of HLA typing with a special attention to ambiguous or poorly defined...

Immunotherapy

07/01/2015

Cancer has become one of the biggest killers in the western world. High profile campaigns to tackle breast cancer and other common types have ensured that it is also one of the biggest businesses in modern medicine. To fight a high profile killer you need the best of cures. Immunotherapy...

Omixon Collaborates with G3 and Genomics England to Validate HLA Genotyping from WGS Data

24/09/2014

Omixon has announced a collaboration with the Global Genomics Group (G3) to validate its Target HLA™ software to determine HLA genotypes from whole genome datasets. G3 is providing the whole genome datasets and the corresponding DNA samples of 340 subjects enrolled in the clinical trial called Genetic Loci and the...

The Ethics of Preimplantation HLA Testing is Debated at the MEMBS Meeting

14/09/2014

The life of some children with hematological malignancies can be saved by the cord blood of their newborn siblings. Parents may chose to have another child in the hope of conceiving an HLA-identical donor sibling. However, there is only 25% chance that siblings will be perfect HLA-identical and the cord...

Cancer Biomarkers

21/08/2014

When tackling any disease, the first step is to learn what signals its presence and what else these signs can mean. In discussing cancer, these signs are referred to as cancer biomarkers. Some organisations define a biomarker as a molecule that the cancerous tumor has secreted into the body, a...