Omixon licensing relies on physical properties of a machine – like the machine ID under Linux or the MAC address on a Windows machine. Due to this virtualization is not supported at the moment, however if you can guarantee that these properties will not change there is no theoretical problem with running Twin or Explore on a virtual machine. In case one of these properties changes the database will be lost which means you need to obtain a new license and re-create user accounts to overcome this issue. Results are not affected by this.