Genotyping Engine Race – Measuring Performance

01/06/2016

Designing an Experiment Designing a validation study for any kind of tool can be a great challenge. For cutting edge technology, this challenge can be even greater. In this blog post I’ll try to cover some problematic aspects and methodological challenges that one can bump into when validating an...

Fact or Fiction – Noise Filtering

19/04/2016

Distinguishing between fact or fiction is not only hard after a bottle of wine but also when looking at the short read pileups and turning our head around day and night while analysing NGS data. When deciding upon a block of short reads if they are representing a valid...

The Dancing Pipettes

17/03/2016

Welcome to the lab! Do you know the feeling when you leave your perfectly prepared library running on the sequencer on Friday, come back on Monday to see your data, and… Everything is totally different than what you are expecting? Yes, we know this too. Let’s take a tour...

Knowledge Exchange – Things Common in Yeast and Humans

27/01/2016

In our Genome Browser we can see both exons, introns and UTRs all the time – they are represented as lines in a sequence of letters ACTAGACTA…. In real molecules they are not linear, but are arranged into a peculiar 3D structure. Later, genes transcribed to this pre-messenger RNAs...