HLA Explore™

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HLA EXPLORE DOWNLOADS ARE AVAILABLE FOR YOUR CONVENIENCE

Whether you are looking for Product Sheets or any other type of support, feel free to browse and download any document of interest. 

Product Sheets and Technical Documents

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  • Release Notes
  • Documentations (Handbook and User Guide)
  • Data Sets
  • IMGT HLA database bundles
Release Notes

Omixon HLA Explore 2.0.0

  • Whole gene analysis support for Statistical Genotyping
  • ABO and MICA genotyping support
  • New allele database structure and format

Omixon HLA Explore 1.7.0

New features and improvements

  • IMGT/HLA 3.29.0.1_5 database version was released:
    • HLA-DRB1*09:01:02 allele extension was removed
    • Erroneous HLA-DRB1*14:13 allele sequence was replaced with record from IMGT/HLA 3.30.0
    • The database was validated with the following software versions: Omixon HLA Twin 2.1.3 CE & RUO, Omixon HLA Twin 2.1.4 CE & RUO and Omixon HLA Twin 2.5.0 RUO. For other software versions, each laboratory is advised to do its own internal validation.
  • Distributed typing service allows for batch analysis and filtering tasks to run in parallel in a client-server environment
  • Existing user accounts cannot be deleted through the UI; administrators have the option to disable and reactivate them whenever needed
  • New export options:
    • JSON export for result files
    • Export result files to PDF/HML with or without LD data
  • Re-Analyse button for result files added
  • File system access rights are now considered on the HLA Typing dashboard: inaccessible folders are marked red and cannot be clicked
  • Pause/resume option for analysis tasks was removed from client-server installations
  • Improved “Targeted Gene List” loading when configuring analysis

Bugfixes

  • Temporary file cleanup fix to avoid losing files still in use
  • Fix for inconsistent display of missing genotype markups
  • Amino acid track fixes for special cases
  • HML export fix: best matching alleles are always exported now
  • Bugs related to result approval were fixed:
    • Commenting on approved results isn't possible any more
    • Result approval buttons work consistently with all precision settings
Omixon HLA Explore 1.4.2

Improvements and bug fixes

  • IMGT/HLA 3.28.0 released
Known limitations
  • Big data QC thresholds are not suitable for all data types
Omixon HLA Explore 1.4.1

Improvements and bug fixes

  • Big data parameters fixed
  • Inconsistent clinical workflow step based filtering fixed
  • Consistent naming convention for extended allele handling
  • Targeted locus list handling fixed in protocols
  • Temp folder is now created by the application if a non-existing folder was specified during installation
  • Null allele postfix no longer gets trimmed in low resolution PDF and HML exports
  • Temporary file cleanup improved
Known limitations
  • Big data QC thresholds are not suitable for all data types

Omixon HLA Explore 1.4.0

New features
  • PacBio analysis (alpha) available
    • Standalone toolset for hdf5 conversion and demultiplexing
    • Built-in analysis pipeline
  • Big data analysis option for whole exome and whole genome data added to Advanced HLA typing wizard.


Improvements and bugfixes

  • Context sensitive guide for the HLA browser
  • Linkage Disequilibrium (LD) improvements
    • Extended LD checks to cover DQB1 and DQA1 in addition to DRB3/4/5
    • Fixed known display issues with DRB3/4/5 results
  • Improved memory settings
    • On first use popup, warning if insufficient memory configured
    • Recommendation for memory settings on installation

Omixon HLA Explore 1.3.0

New features

  • PacBio analysis (alpha) available
    • Standalone toolset for hdf5 conversion and demultiplexing
    • Built-in analysis pipeline
  • Big data analysis option for whole exome and whole genome data added to Advanced HLA typing wizard.

Improvements and bugfixes

  • Context sensitive guide for the HLA browser
  • Linkage Disequilibrium (LD) improvements
    • Extended LD checks to cover DQB1 and DQA1 in addition to DRB3/4/5
    • Fixed known display issues with DRB3/4/5 results
  • Improved memory settings
    • On first use popup warning if insufficient memory configured
    • Recommendation for memory settings on installation

Omixon HLA Explore 1.2.0

Improvements and bugfixes

  • Big data filter option fixed
  • New browser options
    • Amino acid track added to browser
    • Fragment visualization in the genome browser
  • Comment history, improved commenting
  • Locus selection in advanced genotyping wizard, improved default targeted locus set selection
  • Improved assignment functions
  • Reduced display length of sample and result names, better representation of duplicate analyses
  • HML and PDF export improvements
  • Improved support for clinical workflows
  • Separate QC metrics for key and non-key exons, QC metrics table reorganized
  • Precision reduction in main results table
  • Several other minor bugfixes and improvements

Known limitations

  • LD based zygosity detection for DRB345 and markups are not always correct

Omixon HLA Explore 1.0.0.3

  • Linkage disequilibrium based result interpretation and annotation improvements
  • Server automation bug fix to create alignments during analysis
  • Several other small bug fixes

Omixon HLA Explore 1.0.0.2

  • Linkage disequilibrium based result interpretation and annotation improvements
  • Server automation stability and performance improvements
  • Several other small bug fixes

Omixon HLA Explore 1.0.0.1

  • Linkage disequilibrium based result interpretation and annotation fixes
  • Customization of the reporting-center-context attribute in the HML export
  • Option to add custom hemizygous genotype
  • Fixed empty result presentation for loci without data
  • Fixed product name in the installer file name
  • Increased maximum memory setup limit to 512GB
  • Several other small bug fixes

Omixon HLA Explore 1.0.0.0

  • Analysis improvements
    • Integrated whole genome (WGS) and whole exome (WES) data filtering
  • Reporting improvements
  • Usability improvements
    • Notification about new IMGT/HLA database availability
    • Higher quality sequence alignments in the genome browser
  • Time based licensing scheme
    • Data type modules
      • Base module for targeted HLA data

      • Big data module for whole genome (WGS) and whole exome (WES) data

    • Deployment specific licenses
      • Desktop
      • Server

Data Sets for Big Data module (WES and WGS)

A new data set is coming soon.