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- Release Notes
- Documentations (Handbook and User Guide)
- Data Sets
- IMGT HLA database bundles
Omixon HLA Explore 2.0.0
- Whole gene analysis support for Statistical Genotyping
- ABO and MICA genotyping support
- New allele database structure and format
Omixon HLA Explore 1.7.0
New features and improvements
- IMGT/HLA 3.29.0.1_5 database version was released:
- HLA-DRB1*09:01:02 allele extension was removed
- Erroneous HLA-DRB1*14:13 allele sequence was replaced with record from IMGT/HLA 3.30.0
- The database was validated with the following software versions: Omixon HLA Twin 2.1.3 CE & RUO, Omixon HLA Twin 2.1.4 CE & RUO and Omixon HLA Twin 2.5.0 RUO. For other software versions, each laboratory is advised to do its own internal validation.
- Distributed typing service allows for batch analysis and filtering tasks to run in parallel in a client-server environment
- Existing user accounts cannot be deleted through the UI; administrators have the option to disable and reactivate them whenever needed
- New export options:
- JSON export for result files
- Export result files to PDF/HML with or without LD data
- Re-Analyse button for result files added
- File system access rights are now considered on the HLA Typing dashboard: inaccessible folders are marked red and cannot be clicked
- Pause/resume option for analysis tasks was removed from client-server installations
- Improved “Targeted Gene List” loading when configuring analysis
Bugfixes
- Temporary file cleanup fix to avoid losing files still in use
- Fix for inconsistent display of missing genotype markups
- Amino acid track fixes for special cases
- HML export fix: best matching alleles are always exported now
- Bugs related to result approval were fixed:
- Commenting on approved results isn't possible any more
- Result approval buttons work consistently with all precision settings
Improvements and bug fixes
- IMGT/HLA 3.28.0 released
- Big data QC thresholds are not suitable for all data types
Improvements and bug fixes
- Big data parameters fixed
- Inconsistent clinical workflow step based filtering fixed
- Consistent naming convention for extended allele handling
- Targeted locus list handling fixed in protocols
- Temp folder is now created by the application if a non-existing folder was specified during installation
- Null allele postfix no longer gets trimmed in low resolution PDF and HML exports
- Temporary file cleanup improved
- Big data QC thresholds are not suitable for all data types
Omixon HLA Explore 1.4.0
- PacBio analysis (alpha) available
- Standalone toolset for hdf5 conversion and demultiplexing
- Built-in analysis pipeline
- Big data analysis option for whole exome and whole genome data added to Advanced HLA typing wizard.
Improvements and bugfixes
- Context sensitive guide for the HLA browser
- Linkage Disequilibrium (LD) improvements
- Extended LD checks to cover DQB1 and DQA1 in addition to DRB3/4/5
- Fixed known display issues with DRB3/4/5 results
- Improved memory settings
- On first use popup, warning if insufficient memory configured
- Recommendation for memory settings on installation
Omixon HLA Explore 1.3.0
New features
- PacBio analysis (alpha) available
- Standalone toolset for hdf5 conversion and demultiplexing
- Built-in analysis pipeline
- Big data analysis option for whole exome and whole genome data added to Advanced HLA typing wizard.
Improvements and bugfixes
- Context sensitive guide for the HLA browser
- Linkage Disequilibrium (LD) improvements
- Extended LD checks to cover DQB1 and DQA1 in addition to DRB3/4/5
- Fixed known display issues with DRB3/4/5 results
- Improved memory settings
- On first use popup warning if insufficient memory configured
- Recommendation for memory settings on installation
Omixon HLA Explore 1.2.0
Improvements and bugfixes
- Big data filter option fixed
- New browser options
- Amino acid track added to browser
- Fragment visualization in the genome browser
- Comment history, improved commenting
- Locus selection in advanced genotyping wizard, improved default targeted locus set selection
- Improved assignment functions
- Reduced display length of sample and result names, better representation of duplicate analyses
- HML and PDF export improvements
- Improved support for clinical workflows
- Separate QC metrics for key and non-key exons, QC metrics table reorganized
- Precision reduction in main results table
- Several other minor bugfixes and improvements
Known limitations
- LD based zygosity detection for DRB345 and markups are not always correct
Omixon HLA Explore 1.0.0.3
- Linkage disequilibrium based result interpretation and annotation improvements
- Server automation bug fix to create alignments during analysis
- Several other small bug fixes
Omixon HLA Explore 1.0.0.2
- Linkage disequilibrium based result interpretation and annotation improvements
- Server automation stability and performance improvements
- Several other small bug fixes
Omixon HLA Explore 1.0.0.1
- Linkage disequilibrium based result interpretation and annotation fixes
- Customization of the reporting-center-context attribute in the HML export
- Option to add custom hemizygous genotype
- Fixed empty result presentation for loci without data
- Fixed product name in the installer file name
- Increased maximum memory setup limit to 512GB
- Several other small bug fixes
Omixon HLA Explore 1.0.0.0
- Analysis improvements
- Integrated whole genome (WGS) and whole exome (WES) data filtering
- Reporting improvements
- Allele frequency reporting based on the database of www.allelefrequencies.net
- Usability improvements
- Notification about new IMGT/HLA database availability
- Higher quality sequence alignments in the genome browser
- Time based licensing scheme
- Data type modules
- Base module for targeted HLA data
-
Big data module for whole genome (WGS) and whole exome (WES) data
- Deployment specific licenses
- Desktop
- Server
- Data type modules
A new data set is coming soon.
New format for versions from/after Twin 3.0.0 and Explore 2.0.0
- 3.51.0_9
- 3.50.0_9
- 3.49.0_9
- 3.48.0_9
- 3.47.0_9
- 3.46.0_9
- 3.45.1_9
- 3.44.1_9
- 3.43.0_9
- 3.42.0_9
- 3.41.2_9
- 3.40.0_9
- 3.39.0_9
- 3.38.0_9
- 3.38.0_8
- 3.37.0_8
- 3.36.0_8
- 3.35.0_8
- 3.34.0_8
- 3.33.0_7
- 3.32.0_7
- 3.32.0_5
- 3.31.0_5
- 3.30.0_5
- 3.29.0.1_5
- 3.28.0_4
- 3.27.0_3
- 3.26.0_3
- 3.25.0_3
- 3.24.0_2
- 3.24.0_1
- 3.21.0
- 3.20.0
- 3.19.0
- 3.17.0
- 3.16.0
- 3.15.0
- 3.14.0
- 3.10.0
Old format for versions before Twin 3.0.0 and Explore 2.0.0